Prof. Ramesh Chandra

(Professor)

Email:rchandra@chemistry.du.ac.in
Website:http://professorrameshchandra.com
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Prof. Ramesh Chandra

Prof. Ramesh Chandra is a distinguished scientist; Fellow of the Royal Society of Chemistry, London and an outstanding researcher in the field of Biomedical Sciences. He is Founder Director of Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi. He has been Vice-Chancellor, Bundelkhand University, Jhansi for six years (1999-2005) as well as the President of the Indian Chemical Society (2004-2006), Member, Planning Commission, Government of U.P., India and Secretary - Zaheer Science Foundation, New Delhi, Non-Official Director, Rashtriya Ispat Nigam Ltd (RINL). Professor Chandra shows deep commitment to the cause of higher education and research and possess in ample measure, quality of dynamic leadership and a vision required for building academic institutions. Professor Chandra started his research career at the University of Delhi, thereafter he went to The New York Hospital-Cornell University Medical Center and the Rockefeller University, New York; State University of New York at Stonybrook as Assistant Research Professor. He conducted advanced research at the Harvard University Medical School-Massachusetts General Hospital, jointly at MIT, Cambridge, USA. Over the last 39 years, Professor Chandra has contributed largely in the field of Chemical Sciences and particularly in New Drug Discovery and Development as well as Drug Metabolism. His research work is being used in the development of drugs for Physiological Jaundice/ Neonatal Jaundice and development of naturally occurring chemotherapeutic agents for the treatment of Breast and Ovarian Cancers, and drugs for Diabetes and Hypertension. He has supervised large number of Ph. D. and M. Phil. Students, in all trained more than 100 research scholars, who are now occupying high positions internationally. He has published more than 260 original Scientific Research Papers in International journals of repute, including Review Articles/Monographs, Book Chapters; Four of his internationally acclaimed Books. Prof. Chandra is the recipient of several professional national/ international recognitions. These includes Award of the Highest Honor of Soka University, Tokyo, Japan (2000); J William Fulbright Scholarship(1993); The Rockefeller Foundation USA-Biotechnology Career Award (1993); UGC Career Award(1993); UGC Research Scientist Award (1988); Rajib Goyal Award for Young Scientists (2002); Lifetime Achievement Award of The Indian Chemical Society (ICS) (2003); Bronze Medal of the Chemical Research Society of India (CRSI) (2004); Prof. Ghanshyam Srivastava Commemoration Award of ICS (2002); Prof. D. P. Chakraborty Commemoration Award of ICS (2001); IMNM-99 Award; Gold Medal in Integrated Medicine for New Millennium (1999); Vidya Ratan Gold Medal (2005) and Dr. BR Ambedkar National Award (2004). He is Fellow of The Royal Society of Chemistry, London; International Academy of Physical Sciences; Institution of Chemists, India and the Indian Chemical Society. He is member of several International Scientific Societies. He has been a member of the Governing Council, BOG, Executive/ Academic Councils of several Universities/ Institutions globally and also Member – U.P Council of Higher Education; U.P. State, Youth Welfare Council and others. He has also been Consultant and Advisor to the various multinational companies like Polaroid Corporation, Diakron Pharmaceuticals, USA, HIKMA Pharmaceuticals-Jordan & currently Consultant to Proviva Pharma, Canada and Director of BIZ SHAKTI, India etc; Advisor to various academic institutions, viz. IIIT-Allahabad & others and also non-official Director of PSU‘s, Govt. of India. Prof. Chandra is a prolific writer and displays extraordinary flair for writing on themes particularly to Higher Education and social issues.

Selected Publications:

  1. Sehrawat H., Kumar N., Tomar R., Kumar L., Tomar V., Madan J., Dass SK., Chandra R., (2020) Synthesis and characterization of novel 1, 3-benzodioxole tagged noscapine based ionic liquids with in silico and in vitro cytotoxicity analysis on HeLa cells. J. Mol. Liq., 112525, http://dx.doi.org/10.1016/j.molliq.2020.112525.
  2. Singh N., Kumar N., Rathee G., Sood D., Singh A., Tomar V., Chandra R., (2020) A Privileged Scaffold Chalcone: Synthesis, Characterization And Its Mechanistic Interaction Studies with BSA employing Spectroscopic And Chemoinformatics Approaches. ACS Omega. DOI http://dx.doi.org/10.1021/acsomega.9b03479.
  3. Rathee G, Singh, N, Chandra R (2020). Simultaneous Elimination of Dyes and Antibiotic with a Hydrothermally Generated NiAlTi Layered Double Hydroxide Adsorbent, ACS Omega DOI 10.1021/acsomega.9b03785.
  4. Tomar V., Kumar N., Dhiman N., Tomar R., Sood D., Dass S.K., Madan J., Prakash S., Chandra R. (2019). Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents. Sci. Rep., 9(1), 1-1
  5. Rathee G., Awasthi A., Sood D., Tomar R., Tomar V., Chandra R., (2019) A New Biocompatible Ternary Layered Double Hydroixde Adsorbent for ultrafast removal of anionic organic dyes. Sci. Rep., 9(1), 114.
  6. Sood D, Kumar N, Singh A, Tomar V, Dass SK and Chandra R (2019). Deciphering the Binding Mechanism of Noscapine with Lysozyme: Biophysical and Chemoinformatic Approaches. ACS Omega, 4, 16233−16241.
  7. Kumar N, Sood D, Tomar R, Chandra R (2019). Antimicrobial peptide designing and optimization employing large-scale flexibility analysis of protein-peptide fragments. ACS Omega, 4(25), 21370-21380.
  8. Singh, S., Rajendran, V., He, J., Singh, A.K., Achieng, A.O., Vandana, Pant, A., Nasamu, A.S., Pandit, M., Singh, J., Quadiri, A., Gupta, N., Poonam, Ghosh, P., Singh, B., Narayanan, L., Kempaiah, P., Chandra, R., Dunn, B., Pandey, K.C, Goldberg, D.E., Singh, A., and Brijesh, R. (2019). Fast-acting small molecules targeting malarial aspartyl proteases, plasmepsins, inhibit malaria infection at multiple life stages. ACS Infect. Dis., 5(2), 184-198.
  9. Kumar, N, Sood, D, Sharma, N, Chandra, R (2019). Multi-Epitope Subunit Vaccine to Evoke Immune Response against Acute Encephalitis. ACS J. Chem. Info. Model. 1-32, https://doi.org/10.1021/acs.jcim.9b01051.
  10. Kaur N, Chugh H, Tomar V, Sakharkar M, Dass SK, Chandra R (2019). Cinnamon Attenuates Adiposity and Affects the Expression of Metabolic Genes in Diet-Induced Obesity Model of Zebrafish. Artificial cells, Nanomed. and Biotechnol., 47(1), 2930-2939.
  11. Chugh H., Kumar P., Tomar V., Kaur N., Sood D., and Chandra R. (2019). Interaction of noscapine with human serum albumin (HSA): A spectroscopic and molecular modelling approach. J. Photochem. Photobiol. A: Chem. 372, 168-176.
  12. Tomar, R., Singh, N., Kumar, N., Tomar, V., and Chandra, R. (2019). Base-Free Suzuki-Miyaura Coupling Reaction Using Palladium (II) Supported Catalyst in Water. Catalysis Letters., 149(6), 1589-1594.
  13. Kumar, N., Chugh, H., Sood, D., Singh, S., Singh, A., Awasthi, A., Tomar, R., Tomar, V. and Chandra, R. (2019). Biology of Heme: Drug Interactions and Adverse Drug Reactions with CYP450, Curr. Top. Med. Chem., 18(23), 2042-2055.
  14. Singh A., Kumar N., Sood D., Singh S., Awasthi A., Tomar V., and Chandra R. (2019). Designing of a Novel Indoline scaffold based Antibacterial Compound and Pharmacological Evaluation using Chemoinformatics approach, Curr. Top. Med. Chem., 18(23), 2056-2065.
  15. Tomar, R., Ebitani, K., and Chandra, R. (2019). Hydrotalcite Supported Ceria Nanoparticles as Heterogeneous Catalyst for One-Pot Synthesis of Imines Under Atmospheric Air, Chem. Select. 4(2), 3577.
  16. Kumar N., Singh A., Grover S., Kumari A., Dhar P. K., Chandra R. and Grover A. (2019). HHV-5 epitope: a potential vaccine candidate with high antigenicity and large coverage. J. Biomol. Struct. Dyn. 37(8), 2098-2109.
  17. Chaudhary M, Kumar N, Baldi A, Chandra R, Babu MA, Madan J (2019). 4-Bromo-4'-chloro pyrazoline analog of curcumin augmented anticancer activity against human cervical cancer, HeLa cells: in silico-guided analysis, synthesis, and in vitro cytotoxicity. J Biomol. Struct. Dyn., 8, 1-19.
  18. Chaudhary, M., Kumar, N., Baldi, A., Chandra, R., Babu, M., and Madan, J. (2019). "Chloro and Bromo-Pyrazole Curcumin Knoevenagel Condensates augmented Anticancer activity against Human Cervical Cancer Cells: Design, Synthesis, In silico Docking and In Vitro Cytotoxicity Analysis: Curcumin Knoevenagel Condensates improved Anticancer activity against Human Cervical Cancer Cells. J. Biomol. Struct. Dyn, 1-19. 2019 Feb 27:1-19. doi: 10.1080/07391102.2019.1578264. [Epub ahead of print]
  19. Sharma A, Sharma D, Baldi A, Jyoti K, Chandra R, Madan J (2019). Imiquimod-oleic acid prodrug loaded cream reduced drug crystallinity and induced indistinguishable cytotoxicity and apoptosis in mice melanoma tumour. J Microencapsu., 36(8), 759-774.
  20. Vishvakarma VK, Singh P, Kumar V, Kumari K, Patel R, Chandra R (2019). Pyrrolothiazolones as Potential Inhibitors for the nsP2B‐nsP3 Protease of Dengue Virus and Their Mechanism of Synthesis. Chemistry Select., 4, 9410-9419.
  21. Bhat A., Mahalakshmi, A.M., Ray B., Tuladhar S., Hediyal A.D., Manthiannem E., Padamati J., Chandra R., Chidambaram S., and Sakharkar M. (2019). Benefits of curcumin in brain disorders. BioFactors. 1-24.
  22. Nagpal, M., Kaur, M., Sharma, D., Baldi, A., Chandra, R. and Madan, J. (2019). Optimization of sulfation of okra fruit gum for improved rheological and pharmacological properties. Int. J. Biol. Macromol., 122, 1-9.
  23. Chidambaram, S.B., Rathipriya, A.G., Bolla, S.R., Bhat, A., Ray, B., Mahalakshmi, A.M., Manivasagam, T., Thenmozhi, A.J., Essa, M.M., Guillemin, G.J., Chandra, R., Sakharkar, M. (2019). Dendritic spines: Revisiting the physiological role. Prog Neuropsychopharmacol Biol Psychiatry. 92, 161-193.
  24. Jyoti K, Jain S, Katare PO, Katyal A, Chandra R, Madan J (2019). Non-small cell lung cancer tumour antigen, MUC-1 peptide-loaded non-aggregated poly(lactide-co-glycolide) nanoparticles augmented cellular uptake in mouse professional antigen-presenting cells. J Microencapsul. 1-15.
  25. Singh N, Singh S, Shubham Sewariya S, Singh A, Rathee G, Sood D, Kumar N, Chandra I, Dass SK, Tomar V, Chandra R (2019). Noscapine as Anticancer Agent & Its Role in Ovarian Cancer. Organic and Medicinal Chemistry, 9 (2), 1-9.2q
  26. Kumari K., Singh P., Bauddh K., Sweta, Mal-lick S. and Chandra R. (2019). Implications of Metal Nanoparticles on Aquatic Fauna: A Review. Nanosc. Nanotechno.-Asia, 9, 30-34.
  27. Kumar, N, Sood, D, Tomar, R, Chandra, R (2019). Emerging Diagnostic Techniques for Lung Cancer Detection. (Book Chapter 7-Recent Trends in Multi displneary Research), Publisher: AkiNik Publications, pp.119-135: ISBN:https://doi.org/10.22271/ed.book.346. https://doi.org/10.22271/ed.book.346 .
  28. Chauhan D., Pooja., Nirbhaya V., Srivastav CM., Chandra R., Kumar S (2020) Nanostructured transition metal Chalcogenide embedded on reduced graphene oxide based highly efficient biosensor for cardiovascular disease detection, Microchemical Journal, Accepted 2019 (In Press).
  29. Rathee G, Kohli S, Singh N., Awasthi A, Chandra, R., (2020). Calcined Layered double hydroxide: Catalyst for Xanthene and 1,4-Dihydropyridine Derivatives synthesis, Applied Clay Science. Oct 2019 (In press).
  30. Sood D., Kumar N., Rathee G., Singh A., Tomar V., and Chandra R. (2018). Mechanistic Interaction Study of Bromo-Noscapine with Bovine Serum Albumin employing Spectroscopic and Chemoinformatics Approaches, Nat. Sci. Rep. 8(1), 16964.
  31. Sood D., Kumar N., Singh A., Sakharkar M. K., Tomar V. and Chandra R. (2018). Antibacterial and Pharmacological Evaluation of Fluoroquinolones: A Chemoinformatics Approach. Genomics Inform., 16(3), 44-51.
  32. Tomar R., Rathee G., Chandra I., Kumar N., Tomar V. and Chandra R. (2018). Synthesis and Characterization of Magnesium Hydroxide & Cerium Oxide Composite: Application in Organic Transformation. Chem. Select, 3, 1645 - 1649.
  33. Tomar R., Sahni A., Chandra I., Tomar V. and Chandra R. (2018). Review of Noscapine and its analogues as potential anti-cancer drugs. Mini-Reviews in Org. Chem., 15(5), 345-363.
  34. Sharma S., Singh N., Tomar V. and Chandra R. (2018). A review on electrochemical detection of serotonin based on surface modified electrodes. Biosens Bioelectron., 107, 76-93.
  35. Kashyap A., Kaur R., Baldi A., Jain U. K., Chandra R. and Madan J. (2018). Chloroquine diphosphate bearing dextran nanoparticles augmented drug delivery and overwhelmed drug resistance in Plasmodium falciparum parasites. Int. J. of Biol Macromol., 114, 161-168.
  36. Sakharkar M. K., Rajamanickam K., Chandra R., Khan H. A., Alhemida A. S., and Yang J. (2018). Identification of novel drug targets in bovine respiratory disease: an essential step in applying biotechnologic techniques to develop more effective therapeutic treatments. Drug Des. Dev. Ther, 12, 1135-1146.
  37. Kumar N., Chugh H., Tomar R., Tomar V., Singh V. K. and Chandra R. (2018). Exploring the interplay between autoimmunity and cancer to find the target therapeutic hotspots. Artificial cells, Nanomed. and Biotechnol., 46(4), 658-668.
  38. Arya G., Kumari M., Gupta N., Kumar A., Chandra R. and Nimesh S. (2018). Green synthesis of silver nanoparticles using Prosopis juliflora bark extract: reaction optimization, antimicrobial and catalytic activities. Artificial Cells Nanomed. Biotechnol., 46(5), 985-993.
  39. Kumar N., Tomar R., Pandey A., Tomar V., Singh V. and Chandra R. (2018). Preclinical Evaluation and Molecular Docking of 1, 3, Benzodioxole Propargyl Ether Derivatives as Novel Inhibitor for Combating the Histone Deacetylase Enzyme in Cancer. Artificial cells, Nanomed. and Biotechnol., 46(6), 1288-1299.
  40. Chugh H., Sood D., Chandra I., Tomar V., Dhawan G. and Chandra R. (2018). Role of gold and silver nanoparticles in Cancer Nano-medicine. Artificial Cells, Nanomed. and Biotechnol., 46(sup1),1210-1220.
  41. Gupta N., Sharma N., Mathur S. K., Chandra R. and Nimesh S. (2018). Advancement in nanotechnology-based approaches for the treatment and diagnosis of hypercholesterolemia. Artificial Cells, Nanomed. and Biotechnol, 46(sup1),188-197.
  42. Baldi A., Chaudhary M., Sethi S., Chandra R. and Madan J. (2018) Armamentarium of nanoscaled lipid drug delivery systems customized for oral administration: In silico docking patronage, absorption phenomenon, preclinical status, clinical status and future prospects. Colloids Surf B Biointerfaces, 170, 637-647.
  43. Singh S., Singh A., Singh M., Sood D., Rathi B., Tomar V., and Chandra R. (2018) Modern Advancement in the Area of Antimalarial Drug Development. Indian J. Het. Chem. 28, 185-194
  44. Bragta P, Sidhu RK, Jyoti K, Baldi A, Jain UK, Chandra R and Madan J. (2018). Intratumoral administration of carboplatin bearing poly (ϵ-caprolactone) nanoparticles amalgamated with in situ gel tendered augmented drug delivery, cytotoxicity, and apoptosis in melanoma tumor, Colloids Surf. B, 166, 339–348.
  45. Manchanda G., Sodhi R. K., Jain U. K., Chandra R. and Madan J. (2018). Iodinated curcumin bearing dermal cream augmented drug delivery, antimicrobial and antioxidant activities. J. Microencapsul. 35(1), 49-61.
  46. Nagpal M., Aggarwal G., Jindal M., Baldi A., Jain U. K., Chandra R. and Madan J. (2018). Ultrasound, microwave and Box-Behnken Design amalgamation offered superior yield of Gu, from Abelmoschus esculentus: Electrical, chemical and functional peculiarity. Comput. Electron. Agric., 145, 169 -178.
  47. Kaur A., Jyoti K., Baldi A., Jain U. K., Chandra R., and Madan J. (2018). Selfassembled nanomicelles of amphiphilic clotrimazole glycyl-glycine analogue augmented drug delivery, apoptosis and restrained melanoma tumour progression, Mater. Sci. Eng. C., 89, 75–86.
  48. Soni N., Jyoti K., Jain U. K., Katyal A., Chandra R. and Madan J. (2017).  Corrigendum to "Noscapinoids bearing silver nanocrystals augmented drug delivery, cytotoxicity, apoptosis and cellular uptake in B16F1, mouse melanoma skin cancer cells. Biomed. Pharmacother. 90, 906-913.
  49. Tomar R., Singh N., Rathee G., Kumar N., Tomar V. and Chandra R. (2017). Synthesis and Characterization of Hybrid Mg (OH)2 /CeCO3OH Composite with Improved Activity Towards Henry Reaction. Asian J. Org. Chem., 6, 1728-1732.
  50. Kumari K., Vishvakarma V., Singh P., Patel R. and Chandra R. (2017). Microwave: An Important and Efficient Tool for the Synthesis of Biological potent Organic Compounds. Curr. Med. Chem., 24(41), 4579-4595.
  51. Soni N., Jyoti K., Jain U. K., Katyal A., Chandra R. and Madan J. (2017). Noscapinoids bearing silver nanocrystals augmented drug delivery, cytotoxicity, apoptosis and cellular uptake in B16F1, mouse melanoma skin cancer cells. Biomed. Pharmacother., 90, 906-913.
  52. Sharma A., Kaur A., Jain U. K., Chandra R. and Madan J. (2017). Stealth recombinant human serum albumin nanoparticles conjugating 5-fluorouracil augmented drug delivery and cytotoxicity in human colon cancer, HT-29 cells. Colloids Surf. B: Biointerface, 155, 200 – 208.
  53. Tomar V., kukreti S., Prakash S., Madan J. and Chandra R. (2017). Noscapine and its analogs as chemotherapeutic agent: Current Updates. Curr. Top. Med. Chem., 17(2), 174-188.
  54. Singh V. K., Kumar N. and Chandra R. (2017). Structural Insights of Induced pluripotent stem cell regulatory factors Oct4 and its Interaction with Sox2 and Fgf4 Gene. Adv. Biotechnol. Biochem., 5, 1-8.
  55. Singh V. K., Saini A. and Chandra R. (2017). The Implications and Future Perspectives of Nanomedicine for Cancer Stem Cell Targeted Therapies. Front. Molecular Biosciences, 4: (52).
  56. Arya G., Sharma N., Ahmed J., Gupta N., Kumar A., Chandra R. and Nimesh S. (2017). Degradation of anthropogenic pollutant and organic dyes by biosynthesized silver nano-catalyst from Cicer arietinum leaves. J. Photochem. Photobiol., 174, 90- 96.
  57. Kumar D., Singh P., Chandra R., Kumari K., Kumar M., Meena M. K. (2017). Impact of Gemini Surfactants on the Stability of Insulin using Computational Tools. Nanomed. Biotherapeutic Discov., 7(1), 149.
  58. Vishvakarma V. K., Singh P., Kumari K. and Chandra R. (2017). Rational Design of Threo as Well Erythro Noscapines, an Anticancer Drug: A Molecular Docking and Molecular Dynamic Approach, Biochem. Pharmacol. (Los Angel), 6(3), 1-7.
  59. Singh P., Kumari K. and Chandra R. (2017). Metal (Au, Ag and Cu) NPs in Ionic Liquid: Potential Catalytic System for Organic Reactions. J. Nanomed. Nanotechnol., 8(6), 1-11
  60. Kumari K., Vishvakarma V. K., Singh P., Chandra R., Athar M., Patel R., and Kumar D. (2017). Sulphonylurea, Metformin, TZDs: Potential Drugs to Cure Diabetes. Int. J. Adv. Biomed. 2(1), 25-33.