ritesh_singh

Dr. Ritesh Singh

(Associate Professor)

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Dr. Ritesh Singh comes from the Azamgarh district in UP. He completed his B.Sc. and M.Sc. degrees from the University of Lucknow. He earned his doctoral degree from CSIR-Central Drug Research Institute, Lucknow. He then moved to Fasan Lab (Prof. Rudi Fasan) at the University of Rochester, USA, for his postdoctoral stay, where he worked on chemoenzymatic synthesis (Bio-catalysis). After a short stay at UNIST, Korea, he started his independent career at CSIR-IICT, Hyderabad, as an INSPIRE Faculty. He also received the prestigious JSPS postdoctoral fellowship to conduct research at Kyoto Prefectural University of Medicine (KPUM), Kyoto, JAPAN, with Prof. Takayoshi Suzuki. After serving the National Institute of Pharmaceutical Education and Research (NIPER-Raebareli) for a year as a faculty, he joined the Central University of Rajasthan as an Assistant Professor in June 2019. Since March 2025, he has been working as an Associate Professor at the University of Delhi.

His research area includes:

A) Development of novel synthetic strategies to access biologically relevant scaffolds and natural products via C-H bond functionalization, especially nitrene and carbene chemistry.

B) Development of metal-free approaches to synthesize pharmaceutical important scaffolds by utilizing aza-oxyallyl cations, benzyne, and nitrenium ion chemistry. 

C) Utilization of developed methods to construct molecules for chemical biology/medicinal chemistry to solve the unmet need in the area of drug research and discovery programs. 

Selected Publications:

  1. Deeksha and Ritesh Singh*; Heteroannulation of Arynes with α-Bromodifluorohydroxamates: An Efficient and General Approach to Access 2,2-Difluoro Indoxyls. Org. Lett., 2024, 26, 5682–5688.
  2. Deeksha, Bittu, and Ritesh Singh*; Synthetic strategies for the construction of C3-fluorinated oxindoles. Org. Biomol. Chem., 2023, 21, 6456 – 6467.
  3. Deeksha, Elagandhula Sathish, Kiran, and Ritesh Singh*; Access to Sterically Hindered Thioethers (α-Thioamides) Under Mild Conditions Using α-Halohydroxamates: Application toward 1,4-Benzothiazinones and 4,1-Benzothiazepinones. J. Org. Chem., 2023, 88, 901–908.
  4. Elagandhula Sathish, Ashis Kumar Gupta, Deeksha, Sandeep Kumar Mishra, Devesh M. Sawant, and Ritesh Singh*; Heteroarylation of Congested α-Bromoamides with Imidazo-heteroarenes and Indolizines via Aza-oxyallyl Cations: En route to Dibenzoazepinone and Zolpidem Analogs. J. Org. Chem., 2022, 87, 14168–14176.
  5. Arshad J. Ansari, Ayushi Yadav, Anirban Mukherjee, E. Sathish, Kommu Nagesh and Ritesh Singh*; Metal Free Amination of Congested and Functionalized Alkyl Bromide at Room Temperature. Chem. Commun., 2020, 56, 4804-4807
  6. Ritesh Singh* and Anirban Mukherjee; Metalloporphyrin Catalyzed C-H Amination. ACS Catalysis, 2019, 9, 3604-3617.
  7. A.V.G. Prasanthi, Samiyara Begum, Hemant Kumar Srivastava, Sandip Kumar Tiwari, and Ritesh Singh*; Iron-Catalyzed Arene C—H Amidation using Functionalized Hydroxyl Amines at Room Temperature. ACS Catalysis, 2018, 8, 8369–8375.
  8. Ritesh Singh,* Kommu Nagesh, Doddapaneni Yugandhar, and A.V.G. Prasanthi; Metal and Oxidant Free Modular Approach to Access N-alkoxy Oxindoles via Aryne Annulation. Org. Lett., 2018, 20, 4848–4853.
  9. Ritesh Singh,* Kommu Nagesh, and Matam Parameshwar; Rhodium(II)-Catalyzed Undirected and Selective C(sp2)−H Amination en Route to Benzoxazolones. ACS Catalysis, 2016, 6, 6520-6524.